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Acomplia has been pitched as the blockbuster weight loss drug of the decade and the company manufacturing the drug, Sanofi-Aventis believes that sales will reach $5.2 billion per year by 2010. That is a huge amount of money is involved.
Investors are getting swept up in the buzz, and desperate consumers are falling over themselves to get a chance to try the drug. Acomplia obstruct cannabinoid receptors in the brain. The CB receptors are believed to play an important role in controlling food consumption and dependence / habituation. People often refer to the cannabis-induced munchies or hunger pangs and Acomplia attempts to do the opposite. In the scramble for profits and quick-fix obesity solutions - no one has bothered to ask some questions about the long term side effects. It is up to the health authorities to distinguish what is an "acceptable risk" based on the data from the clinical trials conducted recently.
Carol knows about the risk - and it is anything but acceptable. I recently corresponded with Carol, who participated in an Acomplia drug trial.
With a long history of dieting, Carol started the trial at a weight of 13 stone 1 pound. With a everyday dosage of 20mg. and Carol noticed two immediate reactions; She was less hungry, and she became very tearful and depressed. She started to lose a pound or two on her weight per week without being on a diet or exercise program.
However things started from bad to worse. "I also felt nauseated quite often and in a period of 3 months vomited 6 times. As the trial continued I became more and more depressed. She felt suicidal most of the time and in her desperation to lose weight, Carol stayed on the drug, but slowly descended into psychosis "I couldn’t sleep and when I did I had terrible nightmares". Carol manifested more graphic symptoms of psychosis (such as self-inflicted violence). She has since been on Acomplia medication for over a year, and has gradually improved.